Abstract
A new set of photoactivatable NADPH mimics bearing a thiourea linkage between a diarylbutadiene
and an adenosine moiety functionalized by O-carboxymethyl groups has been designed and synthesized in a convergent strategy.
These compounds display absorption and fluorescence emission maxima in DMSO (λmax,abs = 390 nm and λmax,em = 460 nm, respectively) consistent with the previously described analogues, with
good fluorescence quantum yields (ΦF = 0.35–0.36), as well as two-photon absorption (σ2 = 10.1 GM at λmax,exc = 780 nm). These molecules could be useful photosensitive tools for biological studies,
especially for cellular studies of nitric oxide synthases.
Key words
nitric oxide - nitric oxide synthases - nanotriggers - photoactivation - convergent
synthesis
